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. Author manuscript; available in PMC: 2018 Nov 22.
Published in final edited form as: J Med Chem. 2017 Nov 3;60(22):9275–9289. doi: 10.1021/acs.jmedchem.7b01228

Table 2.

Antiproliferative potency of second generation analogs in TNBC cell lines

GI50 ± SD (μM)
Cmpd MDA-MB-453 SUM-185PE MDA-MB-231 HCC1937 HCC1806 BT-549 A10
24 2 ± 2 3 ± 2 18 ± 3 7 ± 1 16 ± 7 20 ± 10 10 ± 1
25 0.40 n.d. 2.0 n.d. 1.9 1.6 n.d
26 2 ± 1 2.6 ± 0.5 16 ± 3 10 ± 1 17 ± 5 20 ± 10 8.5 ± 0.6
27 0.8 ± 0.3 2.1 ± 0.9 27 ± 5 11 ± 2 22 ± 9 23 ± 8 19 ± 6
28 0.2 ± 0.3 1 ± 1 6 ± 3 3.6 ± 0.2 5 ± 2 6 ± 4 3.3 ± 0.1
29 0.28 n.d. 1.5 n.d. 0.33 1.3 n.d
30 0.8 ± 0.7 1.6 ± 0.4 50 ± 9 35 ± 1 30 ± 20 40 ± 30 35 ± 1
31 1.4 ± 0.9 2.8 ± 0.8 12 ± 1 10 ± 1 20 ± 20 14 ± 7 10.5 ± 0.2
32 1.1 n.d. 2.5 n.d. n.d 8.2 n.d
33 0.48 n.d. 2.5 n.d. 6.0 4.2 n.d
34 0.90 n.d. 5.4 n.d. n.d. 8.8 n.d