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. 2018 Jul 12;2(8):941–955. doi: 10.1002/hep4.1197

Figure 2.

Figure 2

HCC is associated with down‐regulation of enzymes mediating oxidative phosphorylation. Genes that were found down‐regulated 10‐fold or more are shown: subunits of the ATP synthase (A, B), a subunit of the cytochrome C oxidase (C), a subunit of the respiratory chain protein ubiquinol cytochrome C reductase (D), subunits of the NADH dehydrogenase (E‐J), mitochondrial ribosomal RNAs (K, L), a mitochondrial tRNA (M) and pseudogenes for the mitochondrially encoded NADH ubiquinone oxidoreductase core subunits (N‐Q). The importance of pseudogenes on disease is currently under intense debate. These results correspond only to the LR samples and not to the LT or TCGA cohorts. Abbreviations: FC, fold change; CYB, ubiquinol cytochrome C reductase; NADH, nicotinamide adenine dinucleotide; RNR, 16S mitochondrial ribosomal RNA; tRNA, transfer RNA; TP, transfer RNA proline; NT, nontumor; T, tumor. Dots represent values of individual samples. Upper and lower borders of boxes represent upper limits of the third and first quartiles, respectively. Line in the middle of boxes represent the median. Whiskers represent scores outside the middle 50% of values.