Table 1.

Inclusion and exclusion criteria for the MAGDALENA study

Inclustion citeria

Age >18 years. Pregnant in week 9–21 after last menstrual period. Verified moderate depression according to SCID-I (Structured Clinical Interview for DSM IV axis I disorders), with or without a concomitant anxiety disorder, and a clinical evaluation. Ability to use the internet platform for ICBT in Swedish as assessed by the study midwife. Reported ability to participate in all study visits for mother and child.

Exclusion criteria

Reported abuse of alcohol or drugs. Reported serious psychiatric disorder.* Known allergy or idiosyncratic reaction to sertraline. Ongoing medication with antidepressants, mood stabilisers, central stimulants, antiepileptic drugs, opiates, insulin, oral antidiabetics, antiarrhythmics or steroids. A severe somatic disease† that requires medical treatment. A high suicidal risk during screening or when included into the study. These women will be excluded from the study and actively transferred to necessary psychiatric care.

*Psychosis, bipolar disorder, severe melancholic or psychotic depression, severe personality disorder, autism, mental retardation or attention deficit and hyperactivity disorder (ADHD)/attention deficit disorder (ADD) with ongoing drug treatment or contact with specialist psychiatry clinic.

†Severe heart and lung disease, kidney disease, liver disease, diabetes mellitus, epilepsy with drug treatment and any severe somatic disease that requires regular treatment with systemic steroids.