Fig. 3.

The actin and myosin networks are affected by frataxin depletion in cardiomyocytes and improved by paclitaxel and MB treatments. Hearts of 3- to 5-day-old adult male flies were dissected and double-labeled with phalloidin to stain F-actin and an anti-GFP antibody to stain the MHC-GFP fusion protein. MHC:GFP/+; Hand-GS/+ control flies were treated with DMSO (i.e. untreated; top row). MHC:GFP/UAS-fhIR; Hand-GS/+ flies were treated with DMSO (untreated), 30 µM MB or 10 µM paclitaxel. All flies were fed with RU486 during both development (40 ng/ml of food) and adulthood (100 µg/ml). Scale bar: 10 µm.