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. 2018 Jul 20;11(7):dmm033811. doi: 10.1242/dmm.033811

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — The sarcomeric pattern of Sallimus is modified in frataxin-depleted hearts, and improved by paclitaxel and MB treatments. Hearts of 3- to 5-day-old adult male flies were dissected and double-labeled with phalloidin to stain F-actin and an anti-GFP antibody to stain the Sls-GFP fusion protein. Hand-GS/sls:GFP control flies were treated with DMSO (i.e. untreated; top row). UAS-fhIR/+; Hand-GS/sls:GFP flies were treated with DMSO (untreated), 30 µM MB or 10 µM paclitaxel. All flies were fed with RU486 during both development (40 ng/ml of food) and adulthood (100 µg/ml). Scale bar: 10 µm.