Table 1.

The bacterial thiamin biosynthetic enzymes

Gene product	Enzyme function	Protein Data Bank identifier and organism for representative structure
ThiC	Hydroxymethyl pyrimidine synthase	3EPM, Caulobacter crescentus
ThiE	Thiamin phosphate synthase	1G69, Bacillus subtilis
ThiF	Adenyltransferase	1ZUD, Escherichia coli ThiS-ThiF complex
ThiS	Sulfur carrier protein	1ZUD, E. coli ThiS-ThiF complex 1TYG, B. subtilis ThiS-ThiG complex
ThiG	Thiazole synthase	1TYG, B. subtilis ThiS-ThiG complex
ThiO	Glycine oxidase	1NG3, B. subtilis
ThiH	Thiazole synthase	None
ThiI	Sulfur transferase	2C5S, Bacillus anthracis
NifS	Sulfur donor	1EG5, Thermatoga maritima
ThiM	Thiazole kinase	1ESQ, B. subtilis
ThiN	Thiamin pyrophosphokinase	None
ThiD	Hydroxymethyl pyrimidine (phosphate) kinase	1JXI, Salmonella typhimurium
ThiL	Thiamin phosphate kinase	3C9T, Aquifex aeolicus
ThiK	Thiamin kinase	None
Dxs	Deoxy-D-xylulose 5-phosphate synthase	2O1S, E. coli
TbpA	Thiamin binding protein	2QRY, E. coli