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. Author manuscript; available in PMC: 2019 Apr 3.
Published in final edited form as: Adv Synth Catal. 2018 Feb 3;360(7):1493–1498. doi: 10.1002/adsc.201701347

Table 3.

Scope of Aryl Halides 5 in Benzylic C–H Arylation of Methyl Heteroaromatics 1a

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a)

Isolated yield on 0.20 mmol scale; Reactions conducted using 1 (1.0 equiv), aryl chloride (5.0 equiv) and NaOt-Bu (5.0 equiv) in o-xylene (0.10 M) at 130 °C.

b)

Reactions conducted using aryl bromide (6.0 equiv) and NaOt-Bu (6.0 equiv).

c)

Reaction time 18 h.

d)

Reactions conducted using Pd(OAc)2 (10 mol%), cataCXium A (20 mol%), aryl chloride (6.0 equiv) and KOt-Bu (6.0 equiv).

e)

Reactions conducted using aryl chloride (6.0 equiv) and LiOt-Bu (6.0 equiv).