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. 2018 Jun 18;293(31):12199–12208. doi: 10.1074/jbc.RA118.002845

Figure 1.

Figure 1.

A, gross appearance and histological examination of the lung in APE rat. Panel 1, gross appearance of the embolized lung, and the black arrow indicates red and white patches. Panel 2, histological examination of the embolized pulmonary artery, and the black arrow indicates the microsphere injected. B, first part of the experiment was designed to show the expressions of CyPA in plasma and RV tissue and CD147 in RV tissue by time course after APE and to investigate the suitable time point for further research. C, second part of the experiment was designed to examine the role of CyPA–CD147 in RV dysfunction after APE and indicate the potential mechanisms. CsA was administered 15 min before surgery at a dose of 10 mg/kg by slow i.v. infusion for 5 min, and a-CD147 was administered immediately after the APE model's establishment at a dose of 3 mg/kg. a-CD147 = mAb of CD147.