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. 2018 Jun 5;293(31):11984–11995. doi: 10.1074/jbc.RA118.001824

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© 2018 Kritsiligkou et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 3. — The constitutive UPR causes slow growth and shortened longevity in a thioredoxin reductase mutant. A, the growth rate (doubling time) of the indicated strains was determined in YEPD medium. Data shown are the means of three independent biological repeat experiments ± S.D. B, the chronological life span of the indicated strains was determined by propidium iodide staining and flow cytometry analysis. Data represent the percentage of live cells in stationary-phase cultures relative to day 0. C, Ire1 activity was monitored using an SR where the HAC1 ORF has been replaced with GFP (40). Fluorescence was measured by flow cytometry. Significance is shown compared with the WT strain: *, p < 0.05; **, p < 0.01; ***, p < 0.005. AU, arbitrary units.