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EC50 values
| Compound | EC50(FRET) | EC50(ATPase) skeletal acto-S1 | EC50(ATPase) cardiac acto-S1 |
|---|---|---|---|
| μm | μm | μm | |
| Honokiol | 44 ± 2 | >>100 | >>100 |
| Tegaserod | 29 ± 2 | >>80 | 20.2 ± 5.1 |
| Thioridazine | 21 ± 3 | 25 ± 3.0 | 29 ± 6 |
| Flutamide | 15 ± 2 | >NDa | >ND |
| Phenothiazine | 7 ± 2 | >ND | >ND |
| Fluphenazine | 25 ± 4 | 12.9 ± 3.9 | 11.0 ± 3.2 |
| Dantrolene | 48 ± 4 | >ND | >ND |
| Novantrone | 5.4 ± 0.7 | 11.3 ± 3.5 | 11.0 ± 2.0 |
| Carvedilol | 48 ± 5 | >ND | >ND |
| Mefloquine | 21 ± 2 | >ND | >ND |
a ND, not determined.
