Figure 2.

Endorepellin co–up-regulates mitostatin and Parkin downstream of VEGFR2. A–C, immunoblot and quantification of mitostatin and Parkin in HUVEC treated with endorepellin over time. D–F, identical experiments as in A–C in HAEC. G–I, immunoblot and quantification of mitostatin and Parkin in HUVEC treated in combination with endorepellin or SU5416 (30 μm) for 6 h. GAPDH served as an internal loading control for all immunoblots. Quantifications presented in B, C, E, F, H, and I are representative of at least three to four independent biological replicates in HUVEC or HAEC. Statistical analyses presented in H and I were calculated via one-way ANOVA.