Figure 3.
Plasmid maps. Abbreviations: ApR, bacterial ampicillin resistance gene; BGH pA, HSVTk pA, and SV40 pA, corresponding polyadenylation signals; CMV, EF1a, and SV40, corresponding promoters; F1 ori, single-stranded origin of replication of the bacteriophage F1; MTS, mitochondrial matrix targeting sequence of human ornithine transcarbamylase; myc, myc tag epitope; mUNG1, a gene encoding Y147A mutant of the human UNG1; NeoR, G418 and kanamycin resistance gene; ColE1ori, bacterial origin of replication; qPCR mNuclear, qPCR mMito, qPCR hNuclear, qPCR hMito, fragments encompassing nuclear and mitochondrial targets in mouse and human genomes, respectively.