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Communication between type 2 and type 3 taste receptor cells. Type 2 cells contain the GPCRs for sweet, bitter, and umami. Activation by ligands stimulates a G protein cascade, releasing intracellular stores of calcium that causes release of ATP. ATP then binds to P2Y receptors on the type 3 presynaptic cells, resulting in serotonin release to stimulate afferent neurons.
