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. 2016 Oct 18;25(22):4983–4995. doi: 10.1093/hmg/ddw326

Figure 2.

Figure 2

Mouse models of RTT are prone to aberrant cardiac conduction and ventricular arrhythmias. (A) Representative ECG image of sinus pauses. (B and C) Sinus pauses over a 2-h period were quantified and averaged to calculate the hourly rate in both male (NULL) and female (NULL/+) mice. (D) Representative ECG image of aberrant atrioventricular block (AVB). (E and F) The mean hourly rate of AVB was quantified in both male and female (NULL/+) mice. (G) An example of an isolated pre mature contraction (PVC). (H-I) Quantification of PVC’s per hour in male (NULL) and female (NULL/+) mice. (J) ECG trace of an example of non-sustained ventricular tachycardia. (K-L) The mean hourly rate of NSVT in male (NULL) and female (NULL/+) mice. Data presented as mean ± SEM. male n = 5–7 per genotype, female n = 7 per genotype *P < 0.05 **P < 0.01 ***P < 0.01.