Figure 4.

SNPs in the MHC region differentiate the T and other groups of TWB samples. (A) Long-range LD between the top 1,285 SNPs in the MHC region identified by the S-T GWAS for the southern Han Chinese. Many pairs of SNPs showed high degree of LD (r²> 0.9; coloured in red) in the southern Han Chinese. In contrast, no such long-range LD was found in northern Han Chinese (B). (C) Allele frequencies of major alleles (with respect to the T group) of the top SNPs identified in the S-T GWAS. (D) Haplotype similarity heat map of the MHC region of chromosome 6 among the S, N and T groups of TWB. Fifty representative samples were randomly selected from each of the other nine subgroups.