Table 1.

15 probe-mtSNP associations had P < 1.35×${10}^{-8}$ corresponding to 5 unique probes. 10 probe-mtSNP associations were significant in a male-specific analysis, and 5 were significant in a female-specific analysis, with no new associations found. For convenience, we present effect sizes from the sex-specific analyses (β, mal and β, fem columns) with further details presented in Supplementary Materials, Tables S1 and S2. Sex-specific effect sizes statistically significant with P < 1.35×${10}^{-8}$ are highlighted in bold

		Probe					Mitochondrial SNP					Fehrmann Cohort
Chr.	Position	Gene	Probe	mtSNP	MAF	β,full (n = 846)	SE	P	β, mal. (n = 428)	β, fem. (n = 418)	β (n = 452)	SE	P
1	28422819:28422868	SPCS2P4	ILMN1780382	MitoA3481G	0.05	−1.64	0.16	1.51×${10}^{-23}$	−1.53	−1.77	−0.44	0.09	1.92×${10}^{-6}$
1	28422819:28422868	SPCS2P4	ILMN1780382	MitoA10551G	0.06	−1.53	0.16	1.50×${10}^{-21}$	−1.53	−1.50	−0.44	0.09	1.92×${10}^{-6}$
1	28422819:28422868	SPCS2P4	ILMN1780382	MitoT9699C	0.06	−1.43	0.15	1.41×${10}^{-20}$	−1.34	−1.40	−0.40	0.09	1.65×${10}^{-5}$
1	28422819:28422868	SPCS2P4	ILMN1780382	MitoT1191C	0.04	−1.46	0.19	3.92×${10}^{-15}$	−1.28	−1.62	−0.35	0.09	1.69×${10}^{-4}$
MT	8249:8287	MT-CO2	ILMN1821517	MitoG8270A	0.03	−1.74	0.45	1.85×${10}^{-14}$	−1.61	−1.97	−0.36	0.09	1.28x${10}^{-4}$
11	74660418:74660444	SPCS2	ILMN2408645	MitoA3481G	0.05	−1.23	0.16	3.19×${10}^{-14}$	−1.33	−1.12	−0.18	0.09	0.06
11	74660418:74660444	SPCS2	ILMN2408645	MitoA10551G	0.06	−1.19	0.16	6.35×${10}^{-14}$	−1.33	−1.01	−0.18	0.09	0.06
5	99383348:99383397	MTND5P12	ILMN1743078	MitoC295T	0.12	0.91	0.12	8.75×${10}^{-14}$	0.92	0.94	0.34	0.09	3.32×${10}^{-4}$
11	74660418:74660444	SPCS2	ILMN2408645	MitoT9699C	0.06	−1.13	0.15	1.01×${10}^{-13}$	−1.34	−0.92	−0.14	0.09	0.13
5	99383348:99383397	MTND5P12	ILMN1743078	MitoC464T	0.10	0.99	0.13	1.13×${10}^{-13}$	1.00	0.95	0.37	0.09	6.58×${10}^{-5}$
5	99383348:99383397	MTND5P12	ILMN1743078	MitoT491C	0.14	0.85	0.12	5.06×${10}^{-13}$	0.86	0.86	0.28	0.09	2.72×${10}^{-3}$
MT	8249:8287	MT-CO2	ILMN1821517	MitoT5005C	0.02	−1.76	0.60	2.91×${10}^{-9}$	−1.62	−2.06	−0.20	0.09	0.03
MT	8249:8287	MT-CO2	ILMN1821517	MitoA14583G	0.02	−1.82	0.62	6.76×${10}^{-9}$	−1.69	−2.06	−0.20	0.09	0.03
MT	8249:8287	MT-CO2	ILMN1821517	MitoA4025G	0.02	−1.81	0.62	7.24×${10}^{-9}$	−1.68	−2.06	−0.20	0.09	0.03
3	100414192:100414241	ADGRG7	ILMN2125395	MitoT217C	0.02	2.01	0.35	1.01×${10}^{-8}$	2.10	1.98	−0.15	0.09	0.11