Table 1.

Former and current Clinical and Laboratory Standard Institute susceptibility breakpoints for penicillin for treatment of Streptococcus pneumoniae infection.

Period, syndrome and route of administration	MIC μg/mL, by susceptibility category
	Susceptible	Intermediate	Resistant
Before January 2008	< 0.06	0.12–1	>2
After January 2008 to present
For meningitis via intravenous route	< 0.06	None	> 0.12
For nonmeningitis syndrome
Via intravenous administration	< 2	4	>8
Via oral administration	< 0.06	0.12–1	>2

MIC: Minimum Inhibitory Concentration