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. 2016 Oct 29;25(23):5059–5068. doi: 10.1093/hmg/ddw310

Figure 1.

Figure 1.

Down-regulating Pink1 or Parkin in Drosophila partially rescues retinal degeneration in flies expressing Wt- or P525L-mutant FUS. (A) Bright field microscopy (A) of fly eyes show that RNAi against Pink1 or Parkin (siPink1 or siPark, respectively) mitigates retinal degeneration caused by Wt- or P525L-mutant FUS, whereas overexpression of Pink1 exacerbates the eye phenotype in flies expressing the P525L-mutant FUS. (B) Scanning EM (SEM) images showing areas of the fly eyes with restored ommatidial organization. Scale bars in panel B: 100 μm (upper panels) or 20 μm (lower panels at higher magnification of SEM). (C) The down-regulation of Pink1 and Park gene expression was verified by RT-PCR.