Table 1.

Trans-ethnic meta-analysis association results for three known HSCR-associated loci

				European GWAS			Asian-specific meta-analysis			Trans-ethnic meta-analysis
											99% credible set
Locus	Lead SNP	Position	Allelea	EAFb	OR (95%CI)	P	EAF	OR (95%CI)	P	LogBF	Number of SNPs	Interval (bp)
RET	rs2505998	10: 43570925	A/G	0.64/0.22	4.17 (3.23–5.26)	1.1 × 10−28	0.82/0.48	3.57 (2.94–4.35)	4.44 × 10−43	67.25	13	15 913
NRG1	rs7005606	8: 32401501	G/T	0.54/0.42	1.64 (1.25–2.15)	4.0 × 10−4	0.36/0.21	2.12 (1.70–2.63)	1.11 × 10−11	11.68	29	31 993
SEMA3C/3D	rs80227144	7: 84349842	A/C	0.14/0.03	5.2 (3.09–8.73)	4.7 × 10−10	0/0	–	–	7.99	13	603 138

^aEffect allele/other allele.

^bEffect allele frequency of cases/controls.