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. 2018 Sep 1;139:194–204. doi: 10.1016/j.neuropharm.2018.07.009

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 4 — Functional characterisation of furosemide on α7 nAChR, 5-HT_3AR and an α7/5-HT_3AR chimera. The effect of furosemide was examined with either a maximal or an EC₅₀ concentration of agonist (A and B, respectively). A) Furosemide (1 mM) was pre- and co-applied with a maximal concentration of agonist (3 mM ACh for α7 and α7/5-HT_3AR chimera; 30 μM 5-HT for 5-HT_3AR). B) Furosemide (1 mM) was pre and co-applied with an EC₅₀ concentration of agonist (100 μM ACh for α7 and α7/5-HT_3AR chimera; 1 μM 5-HT for 5-HT_3AR). In both cases potentiation of the α7 nAChR was significantly greater than potentiation with the 5-HT_3AR and with the α7/5-HT_3A chimera. Data are means ± SEM (n = 4–8). Significant differences are indicated (**P < 0.01, ***P < 0.001).