Fig. 8.

Influence of α7 nAChR mutations on the allosteric modulatory effect of DB04763, DB08122 and pefloxacin. Data are shown for DB04763 (A), DB08122 (B) and pefloxacin (C). Bar charts illustrate the influence of the compounds (100 μM) on responses to an EC₅₀ concentration of ACh (10 μM for L247A and 100 μM for wild-type and all other mutated receptors). Data are normalised to the response observed in the same oocyte in the absence of the compounds. Data are means ± SEM of at least three independent experiments. Significant differences from wild-type are indicated (*P < 0.05, **P < 0.01, ***P < 0.001). In addition, significant differences from agonist responses in the absence of the compounds are indicated (##P < 0.01, ###P < 0.001).