Table 1.
Pharmacokinetic (PK) parameters of curcumin in Rat plasma.
| Final Population Pharmacokinetic Parameters | ||
|---|---|---|
| Parameter | Estimate (CV%) | Description |
| CL(L/h/kg) | 55.1 (1.76) | Elimination clearance |
| CLD(L/h/kg) | 30.3 (3.12) | Distribution clearance |
| VC (L/kg) | 14.2 (1.05) | Volume of distribution in the central compartment |
| VP (L/kg) | 48.5 (8.89) | Volume of distribution in the peripheral compartment |
| Non-Compartmental Analysis | ||
| AUC(0–6)(ng/mL*h) | 767 (37.4) | Area under the curve from 0 to 6h |
| AUC(0–∞)(ng/mL*h) | 785 (35.9) | Area under the curve from 0 to infinity |
| AUMC(0–6)(ng/mL*h2) | 962 (26.4) | Area under the first moment curve 0 to 6h |
| AUMC(0–∞)(ng/mL*h2) | 1265 (3.7) | Area under the first moment curve 0 to infinity |
| MRT (h) | 1.75 (33.0) | Mean residence time |
| CL (L/h/kg) | 55.7 (36.5) | Total clearance |
| T1/2(h) | 3.36 (42.9) | Elimination half-life |