. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Biopharm Drug Dispos. 2018 Jun;39(6):289–297. doi: 10.1002/bdd.2136

Table 2.

Pharmacodynamic parameters of iNOS expression estimated from the indirect response model and the indirect response model with transit compartments.

Parameter	Description	Estimates by model
Parameter	Description	IDR only	TC + IDR
K_in (1/h)	Zero-order rate of formation of iNOS mRNA	1.115	0.418
T (h)	Duration of LPS effect	3 (Fixed)	_
K_out (1/h)	Elimination constant of iNOS mRNA	1.496	0.26
K_lps	Stimulation of iNOS mRNA by LPS	131.8	137
IC₅₀ (ng/mL)	50% inhibition of iNOS by Curcumin	5.82	41.6
τ (h)	Transit time	_	0.515
K_m (1/h)	Rate constant for LPS elimination	_	0.947