. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Biopharm Drug Dispos. 2018 Jun;39(6):289–297. doi: 10.1002/bdd.2136

Table 3.

Pharmacodynamic parameters of TNF-α and IL-6 expression estimated from the indirect response model with transit compartments.

Parameter	Description	Estimates by TC+IDR model
Parameter	Description	TNF-α	IL-6
K_in (1/h)	Zero-order rate of formation of TNF-α mRNA	1.49	1.14
K_out (1/h)	Elimination constant of TNF-α mRNA	1.39	0.941
K_lps	Stimulation of TNF-α mRNA by LPS	30.4	33.7
IC₅₀ (ng/mL)	50% inhibition of TNF-α by Curcumin	4.58	7.37
τ (h)	Transit time	0.727	0.941
K_m (1/h)	Rate constant for LPS elimination	0.581	0.946