Table 1.

Performance metrics of “clicked” gene therapeutics compared to other methods.

#	Oligonucleotide/ small molecule	Mechanism of action/Target	Modification	Stability in biofluids	Specificity	Uptake efficacy	Ref
1	MO-DM2	Antisense/r(CCUG) repeat expansion	morpholino	++	+++	++	49
2	PMO-CPP	antisense	morpholino	nd	nd	+++	50
3	P-gp siRNA	siRNA/reducing Pgp expression in breast cancer	“Clicked” triblock copolymer, natural siRNA	+	++	+++	51
4	CD206-siRNA	siRNA/macrophage targeted delivery	Micelle mannosylation by click	++	+++	+++	52
5	LW6	HIV-1 α supressing	Click with a fluorophore	nd	nd	+++	53
6	D/Gal	Induced gene expression/cancer cell	Clicked galactose	nd	++	++	54
7	ADC	anti-CD22 antibody with doxorubicin/lymph oma cancer cell	-	++	+++	+++	55

+ Moderate, ++ High, +++ Very high