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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Eur J Neurosci. 2018 Feb 28;49(6):784–793. doi: 10.1111/ejn.13858

Figure 1.

Figure 1

Diverse NT action in the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA). This schematic indicates the architecture and behavioral roles of specific NT circuits, as well as NT-induced modulation of neurotransmitter signaling in the SNc/VTA. Purple lines and ovals represent sources of NT, including inputs from the LH that either co-express NT and glutamate (NT/glutamate) or express leptin receptors (LepRB). Purple arrows indicate an increase or decrease in signaling at a given synapse, including the responsible receptor subtype (if it is known). The location of the arrow indicates if the effect of NT occurs presynaptically (near the input), postsynaptically (adjacent to the receptor), or was not determined (between the input and receptor). NT release from dopamine neurons is putative and indicates possible retrograde transmission of NT at dendro-dendritic synapses between dopamine neurons.