Table 1.

Neurotensin-induced modulation of neuronal excitability

Brain region	Neuron type	NT receptor(s)	Intracellular signaling	Action	Net effect	References
Amygdala (Basolateral)	Pyramidal	NTS1	--	glutamate/AMPA	Excite	Amano et al., 2008
Basal forebrain	Cholinergic	--	Ca2+	Postsynaptic depolarization	Excite	Alonso et al., 1994
Cerebral cortex	Pyramidal	NTS2	--	GABAA	Inhibit	Case et al., 2017
			--	GABAB
	Fast spiking interneuron	--	--	Depolarization	Excite	Case et al., 2017
Cortex Layer 6b	Slow bursting	--	--	Postsynaptic depolarization	Excite	Combremont et al., 2016
Dentate gyrus	Granule	NTS1	Gαq/11	TASK-3 K+conductance	Excite	Zhang et al., 2015 Zhang et al., 2016
			Gαq/11, calmodulin, myosin light-chain kinase	glutamate/AMPA
Diagonal band of Broca	Cholinergic	NTS1	Ca2+	Depolarization	Excite	Matthews et al., 1999
	Non-cholinergic	--	--	Depolarization	Excite	Jassar et al., 1999
Dorsal raphe nucleus	Serotonergic	NTS1	--	Depolarization	Excite	Jolas & Aghajanian, 1996
Dorsolateral striatum	Medium spiny projection	NTS1 or NTS2	--	endo-cannabinoid glutamate	Excite	Yin et al., 2008
Entorhinal cortex	Pyramidal	NTS1	PLC, PKC	Trek-2 K+conductance	Excite	Xiao et al., 2014
Globus pallidus	--	NTS1	PLC	glutamate	Excite	Chen et al., 2006 Chen et al., 2004
			--	non-selective cation channel conductance
			--	K+ conductance
Hippocampus CA1	Pyramidal	NTS1	PLC, PKC, IP3, Ca2+	GABAA	Inhibit	Li et al., 2008
	Interneuron	NTS1	--	Depolarization	Excite
Hypothalamus	Orexin expressing	NTS1 or NTS2	--	non-selective cation channel conductance	Excite	Furutani et al., 2013
Nucleus of the solitary tract	--	NTS1	--	K+ conductance	Excite or inhibit	Ogawa et al., 2005
			--	GABAA
			--	AMPA
Nucleus raphe magnus	Serotonin	NTS3 or NTS4	Gαq/11, IP3, Ca2+	non-selective cation channel conductance	Excite	Li et al., 2001b
Bed nucleus of the stria terminalis	--	NTS1 or NTS2	--	GABAA	Inhibit	Krawczyk et al., 2013 Normandeau et al., 2017
Parabrachial nucleus	--	NTS1	--	glutamate/AMPA	Excite	Saleh et al., 1997
Periaqueductal gray	--	NTS1	--	Depolarization	Excite	Mitchel et al., 2009 Li et al., 2001a
			--	glutamate/mGlur5
			--	endo-cannabinoid
			--	GABAA
		NTS3 or NTS4	Gαq/11, IP3, Ca2+	Depolarization
Substantia nigra pars compacta	Dopamine	NTS1	Gαq/11, IP3, Ca2+	non-selective cation channel conductance	Excite or inhibit	Shi & Bunney, 1992b Wu et al., 1995 Wu & Wang, 1995 Piccart et al., 2015 Gantz & Bean, 2017 Tschumi & Beckstead, 2018
			PKC	K+ conductance
			PKA	GABAA
		NTS2	--	GABAB
			--	D2
		--	PKA	D2
			--	2-arachidonyl-glycerol
			--	A-type K+ conductance
Supra-chiasmatic nucleus	--	NTS3 or NTS4	--	--	Excite or inhibit	Coogan et al., 2001
Superior colliculus	--	--	--	glutamate sensitivity	Inhibit	Zhang et al., 1996
Ventral tegmental area	Dopamine	NTS1	Gαq/11, PLC	non-selective cation channel conductance	Excite or inhibit	Shi & Bunney, 1992b Jiang et al., 1994 Chien et al., 1996 Kortleven et al., 2012 Kempadoo et al., 2013 Bose et al., 2015 Piccart et al., 2015 Stuhrman & Roseberry, 2015
			PLC	2-arachidonyl-glycerol
			--	glutamate
			--	glutamate/NMDA
		NTS2 or NTS3 or NTS4	Ca2+	glutamate/NMDA/AMPA
		--	--	GABAB
			PKA	D2
	Non-dopamine	NTS2	--	glutamate