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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Hepatology. 2018 May 21;68(2):561–573. doi: 10.1002/hep.29832

Figure 1. MicroRNAs targeting HDAC6 are downregulated in CCA.

Figure 1

A, The expression pattern of miR-433 and miR-22 was analyzed in normal cholangiocytes (NHC) and the CCA cell lines HuCCT-1 and KMCH by q-PCR. In situ hybridization for miR-433 and miR-22 in human cholangiocarcinoma tissues. Green, positive signals; blue, counterstained nuclei with DAPI. B, qPCR for miR-433 and miR-22 in a different cohort of CCA human samples (T) compared to matched surrounding tissue (S) and to normal gallbladders as controls. (*p<0.05, **** p<0.001)