Table 2. IFN-γ and IL-5 responses to a panel of PKS antigens and Antigen85A after diluted whole blood stimulation for 5 days of 24 Mycobacterium ulcerans disease cases.

Cytokines [median(range) pg/ml)]	Antigens	Week 0	Week 8	P-value‡	Week 16	P-value‡‡
Interferon-γ	ACP2	319.1 (0–6,939)	1,004 (13–6,584)	0.0462	ND
	ACP3	33.55 (0–2,054)	1 (0–3,507)	0.3881	ND
	ATac1	1,270 (0–7,753)	28,439 (226–8,776)	0.1108	ND
	ATac2	1,215 (0–7,753)	4,973 (0–12,355)	0.0494	ND
	ATp	449.4 (0–4,269)	770 (0–6,659)	0.2036	1,544 (61–11,066)	0.0294
	ER	3,010 (0–8,855)	4,397 (38–9,064)	0.2808	7,662 (64–11,103)	0.0003
	KR A	2,850 (0–8,797)	3,561 (4–11,288)	0.3887	ND
	KR B	1,004 (0–7,299)	4,851 (25–10,745)	0.0568	ND
	KS C	618.4 (0–7,277)	1,190 (25–8,101)	0.2725	ND
	Ksalt	521.2 (0–7,764)	1,950 (37–8,173)	0.2166	3,803 (136–11,229)	0.0169
	DH	671.2 (0–6,587)	2,037 (44–9,086)	0.077	ND
	Ag85Aulc	307.4 (0–3,440)	2,287 (0–6,735)	0.0551	ND
Interleukin-5	ACP2	26.94 (0–125.1)	52.87 (0–178)	0.1013	ND
	ACP3	24.19 (0–114.4)	45.46 (0–1,396)	0.2089	ND
	ATac1	25.02 (0–179.5)	52.7 (0–286.2)	0.0129	ND
	ATac2	23.22 (0–412.4)	47.46 (0–167.3)	0.9695	ND
	ATp	12.4 (0–85.08)	42.55 (0–144.6)	0.0149	42.35 (5.59–1,071)	0.002
	ER	39.14 (0–415.4)	58.82 (0–189.6)	0.105	39.47 (0–952.4)	0.2511
	KR A	28.07 (0–1,401)	46.34 (0–124.5)	0.1039	ND
	KR B	40.44 (0–245.3)	42.58 (0–148.5)	0.5197	ND
	KS C	19.84 (0–294.6)	36.00 (0–149.7)	0.1284	ND
	Ksalt	17.37 (0–140)	44.19 (0–151.5)	0.1937	43.51 (0–987.1)	0.1067
	DH	20.98 (0–188.2)	28.17 (0–162)	0.4519	ND
	Ag85Aulc	40.06 (0–676.7)	51.9 (0–614.9)	0.2236	ND

Notes:

ND, not done.

^‡Mann–Whitney test comparing baseline (week 0) IFN-γ and IL-5 responses with those of with week 8.

^‡‡Mann–Whitney test comparing baseline (week 0) IFN-γ and IL-5 responses with those of with week 16. P < 0.05 indicate a significant difference.