Table 2. Clinico-pathological factors for adequate lymphadenectomy (multivariable analysis).
| Characteristic | GOG criteria | CGR criteria | Mayo criteria | ||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | ||
| Age (yr) | |||||||
| <40 | 1.00 | 1.00 | 1.00 | ||||
| 40–49 | 1.11 (0.97–1.28) | 0.13 | 1.18 (1.03–1.35) | 0.015 | 1.23 (1.04–1.46) | 0.016 | |
| 50–59 | 1.10 (0.96–1.25) | 0.18 | 1.16 (1.02–1.32) | 0.022 | 1.15 (0.98–1.36) | 0.09 | |
| 60–69 | 0.98 (0.84–1.13) | 0.73 | 1.02 (0.88–1.17) | 0.83 | 0.96 (0.80–1.14) | 0.61 | |
| ≥70 | 0.70 (0.60–0.81) | <0.001 | 0.74 (0.63–0.85) | <0.001 | 0.72 (0.59–0.88) | 0.001 | |
| Race | |||||||
| White | 1.00 | 1.00 | 1.00 | ||||
| Black | 0.63 (0.53–0.76) | <0.001 | 0.75 (0.62–0.89) | 0.001 | 0.75 (0.58–0.96) | 0.024 | |
| Hispanic | 0.90 (0.79–1.02) | 0.10 | 0.92 (0.81–1.04) | 0.17 | 1.01 (0.87–1.12) | 0.90 | |
| Asian | 0.86 (0.75–0.97) | 0.017 | 0.93 (0.82–1.05) | 0.21 | 0.88 (0.76–1.02) | 0.09 | |
| Others | 0.76 (0.57–1.01) | 0.06 | 0.80 (0.61–1.05) | 0.11 | 0.83 (0.59–1.18) | 0.30 | |
| Year | |||||||
| Before 1990 | 1.00 | 1.00 | 1.00 | ||||
| 1990–1999 | 2.67 (1.91–3.72) | <0.001 | 2.35 (1.61–3.44) | <0.001 | 2.23 (1.16–4.28) | 0.016 | |
| 2000–2009 | 4.28 (3.09–5.94) | <0.001 | 3.59 (2.46–5.22) | <0.001 | 3.70 (1.94–7.04) | <0.001 | |
| 2010 or later | 6.33 (4.53–8.84) | <0.001 | 5.40 (3.70–7.90) | <0.001 | 5.05 (2.64–9.64) | <0.001 | |
| Registry | |||||||
| West | 1.00 | 1.00 | 1.00 | ||||
| Central | 0.76 (0.69–0.84) | <0.001 | 0.73 (0.66–0.80) | <0.001 | 0.67 (0.59–0.77) | <0.001 | |
| East | 0.80 (0.73–0.88) | <0.001 | 0.77 (0.71–0.84) | <0.001 | 0.65 (0.58–0.73) | <0.001 | |
| Marital status | |||||||
| Single | 1.00 | 1.00 | 1.00 | ||||
| Others | 1.06 (0.96–1.16) | 0.26 | 1.08 (0.99–1.18) | 0.09 | 0.98 (0.87–1.09) | 0.66 | |
| Unknown | 1.04 (0.84–1.30) | 0.70 | 0.97 (0.79–1.19) | 0.78 | 0.68 (0.51–0.90) | 0.008 | |
| Cancer stage | |||||||
| I | 1.00 | 1.00 | 1.00 | ||||
| II | 0.88 (0.80–0.96) | 0.003 | 0.87 (0.80–0.95) | 0.001 | 0.92 (0.83–1.03) | 0.13 | |
| Histology type | |||||||
| Serous | 1.00 | 1.00 | 1.00 | ||||
| Endometrioid | 1.14 (1.01–1.28) | 0.037 | 1.08 (0.99–1.18) | 0.14 | 1.03 (0.90–1.19) | 0.67 | |
| Clear cell | 1.15 (1.05–1.27) | 0.004 | 0.97 (0.79–1.19) | 0.007 | 1.06 (0.94–1.19) | 0.36 | |
| Mucinous | 0.95 (0.84–1.07) | 0.42 | 0.87 (0.80–0.95) | 0.035 | 0.84 (0.72–0.98) | 0.026 | |
| Grade | |||||||
| 1 | 1.00 | 1.00 | 1.00 | ||||
| 2 | 0.95 (0.85–1.06) | 0.35 | 0.96 (0.87–1.07) | 0.45 | 0.97 (0.85–1.10) | 0.62 | |
| 3 | 1.07 (0.96–1.21) | 0.22 | 1.05 (0.94–1.17) | 0.39 | 1.07 (0.93–1.23) | 0.35 | |
| Unknown | 0.95 (0.84–1.08) | 0.45 | 0.97 (0.86–1.09) | 0.61 | 1.02 (0.87–1.19) | 0.82 | |
| Tumor size (cm) | |||||||
| ≤10 | 1.00 | 1.00 | 1.00 | ||||
| >10 | 0.96 (0.88–1.05) | 0.38 | 0.98 (0.90–1.06) | 0.6 | 1.04 (0.94–1.15) | 0.47 | |
| Unknown | 0.95 (0.86–1.04) | 0.28 | 0.96 (0.87–1.05) | 0.34 | 1.03 (0.91–1.17) | 0.62 | |
| Hosmer-Lemeshow | p=0.31 | p=0.52 | p=0.12 | ||||
Binary logistic regression models for p-values (adequate vs. inadequate pelvic lymphadenectomy). All the covariates listed were entered in the final models. Significant p-values are emboldened.
CGR, Collaborative Group Report criteria for bladder cancer; CI, confidence interval; GOG, Gynecologic Oncology Group; Mayo, Mayo Clinic criteria for endometrial cancer; OR, odds ratio.