Table 4. The results of multivariate analysis for survival endpoints.
| Variable | OS | RFS | DSS | Locoregional recurrence | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI of HR | p-value | HR | 95% CI of HR | p-value | HR | 95% CI of HR | p-value | HR | 95% CI of HR | p-value | |
| Age (≥50 vs. <50 yr) | 9.22 | 1.20–70.90 | 0.033* | 2.72 | 0.82–9.04 | 0.103 | 9.93 | 0.58–82.30 | 0.125 | 1.62 | 0.36–7.32 | 0.533 |
| RT (yes vs. no) | 0.56 | 0.13–2.54 | 0.455 | 0.32 | 0.10–1.01 | 0.051 | 0.31 | 0.03–3.59 | 0.348 | 0.246 | 0.09–0.70 | 0.009* |
| Grade (2 vs. 1) | 2.30 | 0.46–11.50 | 0.309 | 1.78 | 0.47–6.77 | 0.367 | 1.42 | 0.13–16.00 | 0.754 | 1.08 | 0.27–4.37 | 0.909 |
| Grade (3 vs. 1) | 7.28 | 1.45–36.60 | 0.016* | 5.13 | 1.38–19.10 | 0.017* | 5.97 | 1.06–58.70 | 0.048* | 5.57 | 1.58–19.50 | 0.007* |
| Adjuvant CT (yes vs. no) | 1.33 | 0.28–6.22 | 0.721 | 1.50 | 0.51–4.37 | 0.459 | 2.44 | 0.30–19.70 | 0.405 | 0.27 | 0.02–3.29 | 0.302 |
| Depth of invasion (<1/2 vs. ≥1/2) | 5.10 | 0.90–28.80 | 0.065 | 2.78 | 0.99–7.75 | 0.051 | 2.04 | 0.40–10.40 | 0.391 | 3.32 | 0.67–16.40 | 0.141 |
| LVSI (yes vs. no) | 1.13 | 0.31–4.22 | 0.851 | 1.44 | 0.58–3.56 | 0.433 | 1.37 | 0.17–10.90 | 0.767 | 1.20 | 0.27–5.40 | 0.811 |
CI, confidence interval; CT, chemotherapy; DSS, disease-specific survival; HR, hazard ratio; LVSI, lymphovascular space invasion; OS, overall survival; RFS, recurrence-free survival; RT, radiotherapy.
*p-value <0.05.