Table.
Patient characteristics at enrolment by study group and country
| Standard-of-care group (n=1287) | Intervention group (n=1287) | Malawi (n=1316) | South Africa (n=1258) | |||
|---|---|---|---|---|---|---|
| Age (years) | 39·6 (11·9) | 39·7 (11·6) | 40·1 (11·7) | 39·1 (11·7) | ||
| Sex | ||||||
| Women | 734 (57%) | 727 (56%) | 829 (63%) | 632 (50%) | ||
| Men | 553 (43%) | 560 (44%) | 487 (37%) | 626 (50%) | ||
| New HIV diagnosis | 212 (16%) | 194 (15%) | 208 (16%) | 198 (16%) | ||
| ART status* | ||||||
| Never | 93 (9%) | 121 (11%) | 57 (5%) | 157 (15%) | ||
| Currently taking | 935 (87%) | 926 (85%) | 1021 (92%) | 840 (79%) | ||
| Interrupted | 47 (4%) | 46 (4%) | 30 (3%) | 63 (6%) | ||
| Time on ART (years)† | 3·0 (0·7–6·7) | 3·0 (0·8–6·7) | 3·4 (0·8–7·4) | 2·6 (0·6–5·8) | ||
| TB symptoms reported | ||||||
| Cough | 681 (53%) | 651 (51%) | 611 (46%) | 721 (57%) | ||
| Fever | 747 (58%) | 753 (59%) | 761 (58%) | 739 (59%) | ||
| Night sweats‡ | 540 (42%) | 497 (39%) | 488 (37%) | 549 (44%) | ||
| Weight loss‡ | 875 (68%) | 906 (70%) | 863 (66%) | 918 (73%) | ||
| Any WHO TB symptom | 1164 (90%) | 1152 (90%) | 1187 (90%) | 1129 (90%) | ||
| Clinically suspected TB§ | 495 (38%) | 501 (39%) | 353 (27%) | 643 (51%) | ||
| Previous TB treatment | 309 (24%) | 335 (26%) | 202 (15%) | 442 (35%) | ||
| Body-mass index (kg/m2) | 21·7 (5·8) | 21·6 (5·8) | 20·0 (4·1) | 23·3 (6·7) | ||
| Morbidity at admission | ||||||
| WHO danger sign¶ | 275 (21%) | 277 (22%) | 337 (26%) | 215 (17%) | ||
| Karnofsky score | 60 (50–70) | 60 (50–70) | 60 (50–70) | 60 (50–70) | ||
| CD4 cell count§ | ||||||
| Median (cells per μL) | 222 (80–436) | 231 (78–438) | 219 (86–431) | 236 (70–445) | ||
| <100 cells per μL | 377 (29%) | 371 (29%) | 365 (28%) | 383 (30%) | ||
| Haemoglobin‖ | ||||||
| Median (g/dL) | 10·4 (8·1–12·9) | 10·8 (8·3–12·7) | 10·4 (7·8–12·4) | 113 (8·8–13·1) | ||
| <8 g/dL | 298 (23%) | 289 (22%) | 355 (27%) | 232 (18%) | ||
Data are mean (SD), n (%), or median (IQR). TB symptoms are reported if present for any duration. ART=antiretroviral therapy. TB=tuberculosis.
ART status denominator is the number of patients with a known HIV diagnosis (n=1075 for standard-of-care group and n=1093 for intervention group).
Missing data for 26 patients in Malawi and 26 in South Africa.
Missing data for one patient in South Africa.
Missing data for three patients in Malawi and six in South Africa.
WHO danger signs are one or more of the following: heart rate more than 120 beats per minute, respiratory rate more than 30 breaths per minute, temperature more than 39°C, or being unable to walk unaided.
Missing data for five patients in South Africa.