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. 2018 Aug 6;8:11746. doi: 10.1038/s41598-018-29619-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AR-C124910XX to ticagrelor plasma concentration ratios. Comparison of metabolite to parent drug concentration ratios based on the presence of STEMI (vs. NSTE-ACS) (A), morphine administration (B), DM (C) or smoking status (D). AUC_M/AUC_T: the ratio of area under the plasma concentration-time curve for AR-C124910XX to area under the plasma concentration-time curve for ticagrelor; DM: diabetes mellitus; NSTE-ACS: non-ST-elevation acute coronary syndrome; STEMI: ST-elevation myocardial infarction.