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. 2018 Aug 6;8:11738. doi: 10.1038/s41598-018-30277-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Forest plot of meta-analysis comparing checkpoint inhibitors vs chemotherapy for overall survival by PD-L1 expression. The size of the squares reflects the weight of the study in the meta-analysis. The effect size of individual trial represents the extracted hazard ratio and 95% confidence interval, and pooled effect-size represents the combined hazard ratio and 95% credible interval from meta-analysis. The combined effects were calculated with a Bayesian fixed-effect model. PD-L1: programmed death-ligand-1.