Table 1.
In vivo reprogramming into neurons and cellular integration in the brain
| Cell type | Transcription factors | Chemicals | Induced neurons | References |
|---|---|---|---|---|
| Mouse glia | Neurog2 | Immature/GABA/Glut | 83 | |
| Human astrocytes | Ascl1+Brn2+Myt1 | n. d. | 79 | |
| Mouse astrocytes | Sox2 | Immature/n.d. | 86 | |
| Mouse astrocytes | NeuroD1 | Glut | 42 | |
| Mouse astrocytes | Sox2 | Immature/GABA | 87 | |
| Mouse astrocytes | Sox2 | Immature/Calretinin | 84 | |
| Mouse astrocytes | NeuroD1 + Ascl1 + Lmx1a + miR128 | Dopaminergic | 85 | |
| Mouse astrocytes | Ascl1 | GABA | 40 | |
| Mouse astrocytes | Neurog2 + Bcl2 | Glut | 82 | |
| Human astrocytes | 9 moleculesa | Glut/Chat/GABA/TH | 61 | |
| Human astrocytes | 6 moleculesb | Glut/Chat | 60 | |
| Mouse NG2 | Sox2 | GABA | 39 | |
| Mouse NG2 | NeuroD1 | Glut/GABA | 42 | |
| Mouse NG2 | Ascl1 + Lmx1a + Nurr1 | Glut/GABA | 81 |
aLDN193189, SB431542, TTNPB, Tzv, CHIR99021, VPA, DAPT, SAG, and Purmo
bVPA; Chir99021; Repsox; Forskolin; i-Bet151; ISX9