Fig. 4.

Crystal structure of HIRA(644–1017) reveals a homotrimer. a Overall structure of homotrimeric HIRA(644–1017). Subunits A, B and C are shown in light green, emerald green, and blue, respectively. The loop regions (860–907) are shown in red. b Structure of the HIRA monomer. The β1 and β2 motifs are shown in pink and yellow, respectively. The α-helical domain and the loop region are shown in white and red, respectively. Black triangles indicate residue numbers of HIRA(644–1017). c Trp799 located at the interface between subunits A and B (emerald green). d The CABIN1-binding loop shown in red and highlighting Phe870 and Arg871. The side chain of Arg871 was not visible in the crystal structure. Residues in the α-helical domain are colored white