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. 2017 Jun 19;15(6):630–639. doi: 10.1038/cmi.2017.36

Figure 3.

Figure 3

Immunodeficiency leads to failure in establishing obesity memory. Immunodeficient Rag1−/− mice and C57BL/6J mice that were treated with dexamethasone (dexa) were subjected to a weight gain-loss-regain cycle. Body weight curve (a, c) and body weight increment ratio values during the weight regain period (b, d) were recorded to examine obesity memory in Rag1−/− mice (a, b) and dexa-treated C57BL/6J mice (c, d), respectively. Adoptive transfer of splenocytes was performed to determine the role of immune cells in memorizing obesity. The body weight curves of donor C57BL/6J mice (e, h) and recipient Rag1−/− mice (f, i) and the body weight increment ratios of recipients during HFD feeding (g, j) were recorded after weight loss (e–g) and after 1 month of weight maintenance (h–j), respectively. The cell collection time is indicated by a black arrow. Data are shown as means±s.d. ***P<0.001, unpaired Student’s t-test. §§§ P<0.001, two-way ANOVA followed by the Bonferroni post hoc test. HFD, high fat diet; Ns, no significance.