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. 2018 Aug 6;9:3112. doi: 10.1038/s41467-018-05582-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — NOVA1 binds to a deep intronic sequence in hTERT DR8 and acts as a splicing enhancer to promote the inclusion of exons 7/8 and greater levels of full-length hTERT mRNAs. a Linear model depicting NOVA1 binding to TERT DR8 promoting the inclusion of exons 7/8. b Alternative model of NOVA1 promoting full-length TERT considering RNA:RNA pairing/RNA secondary structure of TERT pre-mRNAs