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. 2018 Aug 6;9:3102. doi: 10.1038/s41467-018-05247-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Overall structure of mTRPC4. a Side and top views of the cryo-EM density map of mouse TRPC4 at 3.3 Å overall resolution. Each monomer is represented in different colors. b Ribbon diagrams of the mouse TRPC4 model with channel dimensions indicated. c Ribbon diagrams depicting structural details of a single subunit. d Linear diagram depicting the major structural domains of the TRPC4 monomer, color-coded to match the ribbon diagram in (c)