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. 2018 Aug 6;9:3102. doi: 10.1038/s41467-018-05247-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — TRPC4 ion conduction pathway. a Ion conduction pathway shown as dots and mapped using HOLE. b Pore radius along the central axis. The side chains of G577 form a narrow constriction at the selectivity filter. N621 is the most restricted site of the lower gate. The dashed line represents TRPM4 for comparison. c Side view of TRPC4’s pore region with chains A and C. The distances between diagonal residues in the selectivity filter and lower gate are labeled. d A putative Na⁺ binding site is found on the cytosolic side in the hydrophilic pocket of the S1–S4 domain. e Enlarged view of putative Na⁺ (orange sphere) ion interacting with E417, Q420, N435, and D438