Fig. 2. KLF12 inhibits embryo implantation.

a Adhesion experiments with BeWo spheroids attached to the Ishikawa cell monolayer with indicated treatments. The data are the average of three independent experiments. ^**P < 0.01 compared with the control group. b Adhesion experiments with mouse embryos attached to the Ishikawa cell monolayer with indicated treatments. The results are expressed as the median with the interquartile range of three independent experiments; boxes indicate quartiles, and whiskers indicate the range. ^**P < 0.01 compared with the control group. c Uteri from KLF12-enhanced and LacZ mice at 4.5 dpc were acquired and stained with Chicago blue dye. The uteri were flushed, and the non-implanted blastocysts were then counted. Representative images are shown. d The number of implantation sites was counted. n is shown in each column. ^***P < 0.001 compared with the control group