Table 3.
Association between the OCT4 and NANOG phenotypes with clinicopathologic parameters.
| OCT4/NANOG Phenotypes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patients and Tumor Characteristics | Total No.Cases 186 (N %) | Condition1 | *P value | Condition2 | *P value | Condition3 | *P value | |||
| Group1 | Group2 | Group1 | Group2 | Group1 | Group2 | |||||
| OCT4Nuclearhigh/NANOG-Nuclearhigh or OCT4Nuclearhigh/NANOG-Cytoplasmichigh | Other phenotypes | OCT4-Nuclearhigh/NANOG Nuclearhigh | Other phenotypes | OCT4Nuclearhigh/NANOG-Cytoplasmichigh | Other phenotypes | |||||
| RCC subtypes | ||||||||||
| ccRCC | 126 (67.7) | 57 (30.6) | 69 (37.1) | 0.012 | 34 (18.3) | 92 (49.5) | 0.116 | 53 (28.5) | 73 (39.2) | 0.004 |
| ChRCC | 29 (15.6) | 22 (11.8) | 7 (3.8) | 13 (7.0) | 16 (8.6) | 22 (11.8) | 7 (3.8) | |||
| pRCC | 31 (16.7) | 16 (8.6) | 15 (8.1) | 12 (6.5) | 19 (10.2) | 14 (7.5) | 17 (9.1) | |||
| Tumor size (cm) | ||||||||||
| <4 | 35 (18.8) | 14 (7.5) | 21 (11.3) | 0.016 | 9 (4.8) | 26 (14.0) | 0.503 | 14 (7.5) | 21 (11.3) | 0.009 |
| 04-Jul | 65 (34.9) | 28 (15.1) | 37 (19.9) | 18 (9.7) | 47 (25.3) | 24 (12.9) | 41 (22.0) | |||
| 07-Oct | 44 (23.7) | 23 (12.4) | 21 (11.3) | 15 (8.1) | 27 (14.5) | 22 (11.8) | 22 (11.8) | |||
| >10 | 42 (22.6) | 30 (16.1) | 12 (6.5) | 59 (31.7) | 27 (14.7) | 29 (15.6) | 13 (7.0) | |||
| Primary tumor (PT) Stage | ||||||||||
| I/II | 74 (39.8) | 35 (18.9) | 38 (20.5) | 0.547 | 21 (11.4) | 52 (28.1) | 0.52 | 31 (16.8) | 42 (22.7) | 0.231 |
| III/IV | 112 (60.2) | 60 (32.4) | 52 (28.1) | 38 (20.5) | 74 (40.0) | 58 (31.4) | 54 (29.2) | |||
| Histological Grade | ||||||||||
| I/II | 94 (50.5) | 38 (24.2) | 56 (35.7) | 0.7 | 23 (14.6) | 71 (45.2) | 0.111 | 34 (21.7) | 60 (38.2) | 0.05 |
| III/IV | 63 (33.9) | 35 (22.3) | 28 (17.8) | 23 (14.6) | 40 (25.5) | 33 (21.0) | 30 (19.1) | |||
| Microvascular invasion(MVI) | ||||||||||
| Positive | 38 (20.4) | 25 (14.2) | 13 (7.4) | 0.03 | 16 (9.1) | 22 (12.5) | 0.345 | 24 (13.6) | 14 (8.0) | 0.076 |
| Negative | 132 (71.0) | 61 (34.7) | 71 (40.3) | 39 (22.2) | 93 (52.8) | 58 (33.0) | 74 (42.0) | |||
*Significances are based on Pearson Chi-square test.
Values in bold are statistically significant.
ccRCC indicates clear cell Renal Cell Carcinoma; chRCC, chromophob Renal Cell Carcinoma; pRCC, papillary Renal Cell Carcinoma.