Figure 4.

Celastrol enhanced the liver oxidative stress and inflammation in LPS-treated mice. A. Levels of an oxidative stress marker MDA in mouse livers under corresponding treatments. B. Relative mRNA expression of inflammatory cytokines of TNF-α, IL-6, IL-18, MCP-1 and ICAM in kidneys. All statistical analyses were performed by one-way ANOVA, followed by a Bonferroni posttest. Data were expressed as mean ± SEM. **P < 0.01 and ***P < 0.001 compared to the Ctrl group; #P < 0.05 and ###P < 0.001 compared to the LPS group.