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. 2018 Jul 15;10(7):1961–1975.

Figure 2.

Figure 2

Treatment with RSV suppressed production of proinflammatory cytokines by upregulating the expression of VEGF-B both in vivo and in vitro. RSV inhibited the inflammatory response both in vivo and in vitro (A) Bronchoalveolar lavage fluid collected at 24 h after surgery to analyze inflammatory cytokines. *P<0.05 compared with the SHAM group, #P<0.05 compared with the CLP group. (B) The mRNA expression levels of TNF-α, IL-1β, and IL-6 (n = 4). Cells were exposed to 100 ng/mL LPS for 1 h. (C) Cell culture media were collected and the concentrations of TNF-α, IL-1β, and IL-6 were measured by ELISA (n = 4) (D) Lungs were harvested 24 h after surgery, and mRNA levels of VEGF-B were quantified by real-time PCR. (D) The mRNA expression levels of VEGF-B in Cells were quantified by real-time PCR (n = 3). *P<0.01 compared with the control group, #P<0.01 compared with the LPS group.