Table 2.
Chemotherapy toxicity according to first-line treatment
| Toxicity and grade | Primary surgery (n = 21) | Initial CT (n = 18) | P value |
|---|---|---|---|
| Hematological toxicitie | |||
| Neutropenia | |||
| All | 20 (95.2%) | 18 (100%) | 1.000 |
| 3-4 | 11 (52.4%) | 11 (61.1%) | 0.748 |
| Anemia | |||
| All | 9 (42.9%) | 6 (33.3%) | 0.742 |
| 3 | 2 (9.5%) | 1 (5.6%) | 1.000 |
| Thrombocytopenia | |||
| All | 10 (47.6%) | 10 (55.6%) | 0.751 |
| 3-4 | 5 (23.8%) | 5 (27.8%) | 1.000 |
| Nausea and vomiting | |||
| All | 16 (76.2%) | 12 (66.7%) | 0.723 |
| 3-4 | 6 (28.6%) | 4 (22.2%) | 0.726 |
| Hepatic dysfunction | |||
| All | 3 (14.3%) | 2 (11.1%) | 1.000 |
| 3-4 | 1 (4.8%) | 1 (5.6%) | 1.000 |
| Renal dysfunction | |||
| 1-2 | 1 (4.8%) | 0 (0%) | 1.000 |
| Alopecia | |||
| 1-2 | 19 (90.5%) | 18 (100%) | 0.490 |
| Mucositis | |||
| All | 4 (19.0%) | 4 (22.2%) | 1.000 |
| 3-4 | 2 (9.5%) | 2 (11.1%) | 1.000 |
| Cardiac toxicities | |||
| Arrhythmia | |||
| 1-2 | 3 (14.3%) | 4 (22.2%) | 0.682 |
| Myocardial ischemia | |||
| 1-2 | 2 (9.5%) | 3 (16.7%) | 0.647 |
| Hemorrhagic cystitis | |||
| 1-2 | 0 (0%) | 1 (5.6%) | 0.462 |
| Dose reduction | |||
| All | 8 (38.1%) | 6 (33.3%) | 1.000 |
Categorical data are presented as numbers (percentages). CT, chemotherapy.