Table 3.
Univariable and multivariable Cox proportional hazard regression analyses of event-free survival
| Factor | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | P | HR (95% CI) | P | |
| Gender | 0.710 | |||
| Male | Reference | |||
| Female | 1.187 (0.482-2.921) | |||
| Age at diagnosis | 0.565 | |||
| < 18 y | Reference | |||
| ≥ 18 y | 0.768 (0.313-1.887) | |||
| Spinal site | 0.663 | |||
| Sacral | Reference | |||
| Nonsacral | 0.830 (0.359-1.917) | |||
| Number of pathological vertebra | 0.486 | |||
| 1 | Reference | |||
| ≥ 2 | 1.348 (0.582-3.126) | |||
| Stage | 0.076 | 0.004 | ||
| Localized | Reference | Reference | ||
| Metastatic | 2.332 (0.915-5.943) | 4.846 (1.655-14.192) | ||
| Diameter of primary tumor | 0.528 | |||
| < 8 cm | Reference | |||
| ≥ 8 cm | 1.315 (0.561-3.082) | |||
| Spinal cord compression | 0.408 | |||
| No | Reference | |||
| Yes | 1.525 (0.561-4.146) | |||
| First-line treatment | 0.016 | 0.003 | ||
| Surgery | Reference | Reference | ||
| Chemotherapy | 0.310 (0.119-0.807) | 0.215 (0.077-0.596) | ||
| Local treatment | 0.475 | |||
| Radiotherapy | Reference | |||
| Surgery + radiotherapy | 1.562 (0.460-5.299) | |||
| En bloc resection of primary tumor | 0.892 | |||
| No | Reference | |||
| Yes | 0.943 (0.403-2.204) | |||
| R0 resection of primary tumor | 0.089 | 0.056 | ||
| No | Reference | Reference | ||
| Yes | 0.451 (0.173-1.180) | 0.375 (0.137-1.026) | ||
HR, hazard ratio; CI, confidence interval; R0 resection, resection with a microscopic negative margin.