Table 1.

Summary of miRNAs dysregulated in LCSCs

MiRNA	Up/Down	Surface marker	Target gene	Related pathway	Reference
let-7b	Down	CD24, CD133	Frizzled4	Wnt/beta-catenin pathway	[56]
let-7a	Down		Wnt1	Wnt signaling pathway, EMT	[57]
miR-21	Up	CD13, EpCAM, CD90, OCT4	PTEN, RECK, PDCD4	STAT3 signaling	[85,115,116]
miR-25	Up		PTEN	PTEN/PI3K/AKT pathway	[109]
miR-33a	Down	Lgr5	ABCB1	Chemo-resistance to doxorubicin	[105]
miR-122	Down	CD133	PDK4	Glycolysis, Smad-independent TGF-beta pathway	[76,110]
miR-125b	Down		Smad2, Smad4	EMT	[73]
miR-130b	Up	CD133	TP53INP1		[75]
miR-137	Down		ANT2	Chemoresistance to sorafenib	[108]
miR-142-3p	Down	CD133	CD133		[111]
miR-145	Down		OCT4		[119]
miR-148a	Down		Smad2, ACVR1, Wnt1	TGF-beta-Smads signaling pathway, BMPs pathway, EMT	[71,72,102]
miR-148b	Down		NRP1		[114]
miR-150	Down	CD133	c-Myb		[112]
miR-152	Down	CD133	KIT		[113]
miR-155	Up	CD90, CD133	TP53INP1, SOCS1	EMT, STAT3 signaling	[74,86,87]
miR-181	Up	EpCAM	CDX2, GATA6	Wnt/beta-catenin signaling pathway	[118]
miR-200a	Down		CTNNB1	Wnt/beta-catenin pathway, EMT	[61,99,100]
miR-200b	Down	CD13, CD24, EpCAM, CD133, CD90	ZEB1	ZEB1 pathway	[101]
miR-205	Down	CD24	PLCbeta 1		[122]
miR-214	Down		CTNNB1	Beta-catenin signaling pathway	[62]
miR-217	Up		DKK1	Wnt signaling pathway	[59]
miR-429	Up	EpCAM	RBBP4	RBBP4/E2F1/OCT4 axis	[120]
MiR-452	Up		SOX7	Wnt/beta-catenin signaling pathway	[63]
miR-491	Down		GIT-1	NF-kappa B pathway, EMT	[103,104]
miR-500a-3p	Up		SOCS2, SOCS4, PTPN11	JAK3/STAT3 pathway	[84]
miR-589-5p	Down	CD90	MAP3K8		[117]
miR-612	Down	CD133	AKT2, Sp1	Wnt/beta-catenin pathway, EMT, Sp1/Nanog signaling pathway	[60,121]
miR-1246	Up			Wnt/beta-catenin pathway	[58]