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. 2018 Aug 6;6(15):e13797. doi: 10.14814/phy2.13797

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Serum C‐reactive protein (CRP) levels are higher in unchallenged Cc16 ^−/− than WT mice at 18 months of age: Serum samples were obtained from unchallenged WT and Cc16 ^−/− mice at 6 months of age (4 mice per group), 12 months of age (5–6 mice/group), or 18 months of age (5 mice/group) via cardiac puncture. Serum CRP levels were measured using an ELISA. The boxes in the box‐plots show the median values and 25th and 75th percentiles, and the whiskers show the 10th and 90th percentiles. Data were analyzed using a one‐way ANOVA followed by pairwise testing with Mann–Whitney U tests. Asterisk indicates 0.05 versus the group indicated or Cc16 ^−/− mice at 6 months of age.