Table 1.

Respiratory mechanics in 6 and 18‐month‐old WT and Cc16 ^−/− mice

Parameter measured	6 Months of age		18 Months of age
	WT n = 11	Cc16 −/− n = 11	WT n = 12	Cc16 −/− n = 13
	Mean (SEM) or Median (IQR)	Mean (SEM) or Median (IQR)	Mean (SEM) or Median (IQR)	Mean (SEM) or Median (IQR)
Tissue elastance (cmH2O/mL)	19.3 (0.6)	17.1 (0.6)a	15.6 (0.7)b	15.1 (0.5)c
Peripheral elastance (cmH2O/mL)	21.0 (18.7–22.5)	18.1 (16.9–19.4)a	17.1 (15.4–19.0)b	16.3 (15.7–17.9)c
Tissue resistance (cmH2O/mL)	3.7 (0.3)	2.9 (0.2)a	3.0 (0.2)b	2.3 (0.07)d
Peripheral resistance (cmH2O/s/mL)	0.5 (0.02)	0.40 (0.01)	0.39 (0.02)b	0.31 (0.01)c , d
Peripheral compliance (mL/cmH2O)	0.047 (0.002)	0.054 (0.002)a	0.057 (0.003)b	0.061 (0.002)c , d

Respiratory mechanics were measured in unchallenged WT and Cc16 ^−/− mice at 6 and 18 months of age in the using a FlexiVent device.

Data are mean ± SEM for data that are normally distributed or medians and interquartile ranges (IQR) for data that are not normally distributed (peripheral elastance values). Data were analyzed with ANOVAs (P < 0.001 for all parameters measured). Pair‐wise comparisons were performed using Student's t‐tests for data that are normally distributed or the Mann–Whitney U tests for data that are not normally distributed.

^a P < 0.05 between 6‐month‐old WT and Cc16 ^−/− mice.

^b P < 0.05 between 6‐ and 18‐month‐old WT mice.

^c P < 0.05 between 6‐ and 18‐month‐old Cc16 ^−/− mice.

^d P < 0.05 between 18‐month‐old WT and Cc16 ^−/− mice.