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. 2018 Jul 31;9:837. doi: 10.3389/fphar.2018.00837

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Copyright © 2018 Chen, Ma, Jiang, Feng, Han, Tang, Zhang, Ni, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Western blot results of ER stress-related factors affected by high dose of TF (75 μg/ml) and lico A (40 μM). (B) RT-qPCR results of ER stress-related factors affected by lico A (40 μM) (^∗P < 0.05 referenced to the control group). (C) RT-qPCR results of apoptosis-related factors affected by lico A (40 μM). (D) High dose of TF (75 μg/ml) and lico A (40 μM) induce no significant aberrant expression of apoptosis-related factors in H292 cells. (E) CHOP expression is repressed by siRNA. (F) Apoptotic nuclear morphology was assessed by fluorescent DNA-binding dye Hoechst 33258. The 10 μM lico A-induced apoptosis (middle) is reversed by the siRNA for CHOP (right).